A new app may help people combat mild symptoms of depression. (PeopleImages.com - Yuri A/Shutterstock)
In a nutshell
- A smartphone app delivering simple cognitive-behavioral skills helped significantly ease mild (subthreshold) depression, with benefits lasting up to six months after use.
- Behavioral activation, encouraging users to engage in enjoyable or meaningful activities, was the most effective single technique, and combining two skills worked even better.
- This digital therapy approach could help millions worldwide who struggle with depressive symptoms but often fall through treatment gaps, offering a low-cost, accessible option for early mental health support.
KYOTO, Japan — Depression exists on a spectrum, but traditional treatment often doesn’t. The estimated 11% of people worldwide with mild depressive symptoms typically fall through healthcare cracks, suffering too much to function well, but not enough to meet clinical thresholds for treatment. Now, new research from Kyoto University reveals these individuals can find significant relief through bite-sized therapy skills delivered right to their phones.
The trial tested five common therapy techniques within a resilience training app called RESiLIENT. It included nearly 4,000 adults with what researchers call “subthreshold depression.” Instead of throwing a bunch of different therapy techniques together and hoping something sticks (the usual approach), researchers tested specific skills to see which ones actually work in this study published in Nature Medicine. Each skill was delivered through app modules and required approximately 20-60 minutes per week of engagement.
Subthreshold depression is a gray zone between feeling fine and meeting the criteria for clinical depression. Symptoms are often serious enough to impact daily life, but many people don’t qualify for treatment programs, which tend to focus on more severe cases and are often costly.
One of the five tested skills is called behavioral activation. It’s basically about getting yourself to do things you enjoy. Another focused on changing negative thought patterns. Others taught problem-solving techniques, ways to express yourself better, and strategies for improving sleep.
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But do they actually work? According to the results, yes, and quite well. All five skills significantly outperformed the control conditions after just six weeks of use. Participants spent roughly 20-60 minutes per week on the app, about the time it takes to watch a single episode of your favorite show.
Behavioral activation was the most effective technique. The app’s benefits lasted long after people stopped regularly using the app. Six months later, participants were still reporting improved mood. Participants weren’t just getting a temporary boost from using a shiny new app; they were actually learning skills that stuck with them.
In mental health research, there’s this idea called the “Dodo bird verdict” that claims all legitimate therapies work equally well. This research says otherwise. Different techniques had noticeably different effects.
The trial had a high completion rate, which is particularly impressive given what we know about digital health tools. If you’ve ever downloaded a fitness app only to abandon it after three days (no judgment here), you understand the challenge. Yet 84% of participants completed the main parts of the program, compared to typical rates for similar unguided internet therapy programs hovering around just 30%.
Why does all this matter? Well, there’s a massive gap between those who need mental health support and those who receive it. Even in wealthy countries, fewer than half of the people with depression get adequate treatment. In developing regions, that number plummets to single digits.
For people with mild symptoms, the situation is even worse. They suffer real impairment – relationship difficulties, reduced work performance, lower quality of life – but often don’t qualify for limited treatment resources. Many are told their problems aren’t serious enough or to come back when things get worse.
That’s a bit like telling someone with pre-diabetes to come back when they develop full-blown diabetes. It makes little sense from both individual health and public health perspectives.
Mental health resources are stretched worldwide. This research offers evidence-based, accessible interventions that target depression before it becomes debilitating. By putting effective therapy techniques literally in people’s hands, we might finally start closing the enormous gap between those who need mental health support and those who receive it.
Paper Summary
Methodology
The RESiLIENT trial (Resilience Enhancement with Smartphone in Living ENvironmenTs) enrolled 3,936 adults across Japan with subthreshold depression, defined as scoring between 5-14 on the Patient Health Questionnaire-9 (PHQ-9) depression scale. Participants were randomly assigned to one of 12 groups: nine intervention arms testing individual cognitive behavioral therapy (CBT) skills or combinations, and three control conditions. The five CBT skills tested were behavioral activation, cognitive restructuring, problem solving, assertion training, and behavior therapy for insomnia. The smartphone app delivered structured lessons and worksheets for each skill, with participants expected to complete one chapter per week. The study used a master protocol design with four embedded 2×2 factorial trials to efficiently test multiple interventions. Participants completed assessments at baseline and weeks 1-6, with follow-up continuing to week 26.
Results
All five CBT skills and their combinations significantly reduced depression symptoms compared to control conditions, with effect sizes ranging from -0.67 to -0.16 for changes in PHQ-9 scores from baseline to week 6. Behavioral activation emerged as particularly effective, and combining skills generally produced stronger effects than individual skills. The benefits persisted for up to 26 weeks, even though most participants dramatically decreased app usage after completing the initial program. The different skills showed varying efficacy for secondary outcomes like anxiety, insomnia, and mental wellbeing. Adherence to the program was remarkably high, with 78% of participants completing the main program contents by week 10 and 84% by week 30.
Limitations
The study acknowledges several limitations. First, participants could not be blinded to their intervention, potentially introducing performance bias. Second, all outcomes were self-reported by participants, which could lead to assessment bias. Third, the study focused on the acute intervention effects and examined durability only up to 26 weeks; longer follow-up would be valuable. Fourth, the researchers examined only five representative CBT skills and didn’t include other potential components like relaxation or mindfulness. Finally, the findings may be limited to the specific smartphone app used in the study and may not generalize to other delivery methods, populations outside Japan, or people with major depressive disorder.
Funding and Disclosures
The study was supported by the Japan Agency for Medical Research and Development. Several researchers reported conflicts of interest, including personal fees from pharmaceutical companies, patents, and licensed intellectual properties related to the app used in the study. The funders had no role in study design, data collection, analysis, interpretation, or writing of the report.
Publication Information
The paper titled “Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial” was published in Nature Medicine on April 23, 2025. The study was registered in the UMIN Clinical Trials Registry (UMIN000047124) on August 1, 2022.