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In a nutshell
- People with cardiovascular conditions have hearts that function nearly 5 years older than their actual age, while those with severe obesity show hearts functioning up to 45 years older.
- The left atrium of the heart shows the most consistent age-related changes, making it an excellent marker for measuring heart aging.
- This new heart age calculation offers doctors a powerful communication tool that may motivate patients to take cardiovascular health more seriously.
NORWICH, England — Your body might be 35, but your heart could be pumping like it’s 80. A team of researchers from the UK, Singapore, and Spain discovered people with conditions like obesity, diabetes, and high blood pressure have hearts functioning as if they’re nearly five years older than their actual age. For those with severe obesity, the numbers are shocking: their hearts may function as if they’re 45 years older than their chronological age.
The Age Gap That Could Save Your Life
Led by Dr. Pankaj Garg from the University of East Anglia’s Norwich Medical School, the international team analyzed cardiac MRI scans from 563 people across five global centers. They compared 191 healthy individuals against 366 participants with cardiovascular risk factors.
They found that the left atrium—the chamber receiving oxygen-rich blood from the lungs—showed the most consistent age-related changes. This chamber naturally grows larger and less efficient as people age, but these changes accelerate dramatically in people with heart problems.
While healthy people’s heart age matched their chronological age, those with risk factors showed hearts functioning almost five years older on average.
Breaking down the data by degree of obesity revealed an even more concerning picture:
- People with mild obesity (BMI 30-34.9) had hearts about four years older than their actual age
- Those with moderate obesity (BMI 35-39.9) showed hearts roughly five years older
- People with severe obesity (BMI over 40) had hearts functioning 45 years beyond their chronological age
Diabetes showed an unusual pattern, with its greatest impact in middle age—diabetics in their 40s had hearts functioning up to 56 years older than healthy peers. High blood pressure consistently aged hearts prematurely until around age 70, while people with atrial fibrillation showed significantly older heart ages across all age groups.
A New Way to Understand Heart Health
Instead of overwhelming patients with complex statistics, doctors can now deliver a simple message: “Your heart is working like someone much older than you.”
“By demonstrating the discrepancy in cardiac and functional age, CMR-derived functional heart age might highlight patients in need of risk factor interventions and help simplify concepts for patients,” the researchers wrote in their paper.
This approach offers a powerful conceptual tool. Rather than decoding complex risk factors, patients can grasp one straightforward fact: their heart is functioning like that of someone decades older.
“People with health issues like diabetes or obesity often have hearts that are aging faster than they should – sometimes by decades. So, this could help doctors step in early to stop heart disease in its tracks,” Dr. Garg explains in a statement. “This is a game-changer for keeping hearts healthier, longer.
What This Means for Medical Standards
The research, published in the European Heart Journal Open, also uncovered fascinating normal changes in heart function throughout aging. The pumping efficiency of the left ventricle—your heart’s main chamber—actually increases with age in healthy individuals, but this beneficial adaptation gets disrupted in people with heart problems.
Current medical standards might need revision to account for these normal age-related changes. The paper notes that “Many accepted measures of cardiac function, including ejection fraction, may require age adjustment to factor in reduced compliance of the heart during healthy aging.”
“Heart disease is one of the world’s biggest killers. Our new MRI method gives doctors a powerful tool to look inside the heart like never before and spot trouble early – before symptoms even start,” says Garg. “By knowing your heart’s true age, patients could get advice or treatments to slow down the aging process, potentially preventing heart attacks or strokes. It could also be the wake-up call people need to take better care of themselves, whether that’s eating healthier, exercising more, or following their doctor’s advice. It’s about giving people a fighting chance against heart disease.”
For the average person, the takeaway is clear: cardiovascular risk factors don’t just increase your chance of heart attack or stroke—they’re actively aging your heart beyond your years. This new way of measuring heart age could motivate more people to take their cardiovascular health seriously through medication, diet, and exercise before serious problems develop.
Paper Summary
Methodology
This international, multicentre, cross-sectional cohort study enrolled 563 participants from five centers across the UK, Spain, and Singapore. Researchers used cardiac MRI scans to measure various heart parameters in both healthy individuals (191 participants with normal BMI and no cardiovascular conditions) and unhealthy individuals (366 participants with one or more conditions like obesity, hypertension, diabetes, or atrial fibrillation). Artificial intelligence-assisted image analysis measured volumes, ejection fractions, and other functional parameters for all four heart chambers. Through statistical analysis, the team identified which cardiac measurements consistently changed with age, ultimately developing equations using left atrial end-systolic volume and left atrial ejection fraction to calculate functional heart age.
Results
In healthy individuals, the calculated functional heart age closely matched chronological age, validating the model. In the unhealthy cohort, functional heart age was significantly higher—about 4.6 years older on average than chronological age. The impact varied by condition: Class III obesity showed the most dramatic effect (heart age 45 years older than chronological age), while diabetes showed age-dependent effects with greatest impact in people’s 40s. The study also documented normal aging patterns for all heart chambers, finding that the left atrium naturally enlarges with age while its efficiency decreases, with these changes accelerated in individuals with cardiovascular risk factors.
Limitations
The researchers acknowledge several limitations. First, the study was retrospective rather than longitudinal, meaning it compared different age groups at a single point in time rather than following individuals as they aged. This makes it potentially susceptible to survivor bias, where people who survived despite having conditions may appear less affected. The duration of comorbidities wasn’t measured, creating heterogeneity in exposure time. Other factors like diet, socioeconomic status, and exercise weren’t assessed. Medical treatments in the unhealthy group may have introduced heterogeneity, and about 1% of cases were excluded due to technical issues with the MRI scans.
Funding and Disclosures
Dr. Garg, who led the study, was funded by a Wellcome Trust Clinical Research Career Development Fellowship. Dr. Garg disclosed being a clinical advisor for Pie Medical Imaging and Medis Medical Imaging, and consulting for Anteris and Edwards Lifesciences. The other authors declared no conflicts of interest. The funders had no role in study design, data collection, analysis, or manuscript preparation.
Publication Information
The paper “Cardiac MRI Markers of Ageing: A Multicentre, Cross-sectional Cohort Study” was published in the European Heart Journal Open on May 2, 2025 by Oxford University Press on behalf of the European Society of Cardiology. The research was registered as ClinicalTrials.gov: NCT05114785.
If that’s the case, my spouse lived to a cardiac output age of 107 while their heart gave out two months after reaching a chronological age of just 62.